Although the severity of the disease and the organs involved determine the choice of specific drugs, a generic treatment strategy is used for all patients with lupus. We advocate strict adherence to the treatment regimen, good sleep hygiene, regular follow-up and monitoring of blood biomarkers. Patients should actively participate in a number of lupus patient associations. Specific aspects of general treatment include the following: 1. UV protection: Avoid exposure to direct or reflected sunlight and UV lamps from other sources (e.g. fluorescent and halogen lamps). Apply UV-A and UV-B lamps with an SPF greater than or equal to 55. 2. Diet and nutrition: There are few studies on the effect of diet on the condition of patients with lupus. A study enrolling 66 lupus patients found that a daily intake of 1.8 g of eicosapentaenoic acid (EPA) and 1.2 g of docosahexaenoic acid (DHA) for 24 weeks significantly reduced the disease activity index (SLAM-R) and significantly improved endothelial cell function. However, until more clinical trials are available, we do not yet recommend that patients supplement their diets with fish oil. A more conservative approach is to recommend a diet with a reasonable mix of carbohydrates, proteins and fats. However, the diet should be moderately adjusted according to the activity index of the disease and the response to treatment. Patients with active inflammatory disease and fever should increase caloric intake; glucocorticoids can increase appetite and lead to significant weight gain. Intake of water, acid suppressants (proton pump inhibitors, H2 receptor blockers) can help suppress appetite. Nephrotic syndrome or glucocorticoid application may lead to hyperlipidemia. Studies have shown that serum cholesterol levels can increase by 7.5 mg/dL (0.2) mmol/L when the daily dose of glucocorticoids is increased by 10 mg. When dietary modification still fails to lower lipids, lipid-lowering drugs should be promptly applied; vitamin supplements are not needed in patients on a balanced diet, but adequate daily supplements are needed in patients who cannot maintain a normal diet and are losing weight. Most patients with SLE have lower than normal serum levels of 25 hydroxyvitamin D, which may be associated with less sun exposure. Patients with low vitamin D levels must take adequate vitamin D supplements . Long-term hormone use and menopausal women should take 800 units of vitamin D and 1500 mg of calcium daily to reduce bone loss; the therapeutic effect of herbal medicine remains to be proven; patients with combined hypertension and nephritis need to adhere to a low-salt diet; overweight patients are encouraged to lose weight. 3, exercise: acute diseases bring long-lasting braking often leads to muscle volume reduction, bone loss and energy loss. Quantitative exercise can help improve these symptoms. Refractory cases can try to use antimalarial drugs to relieve symptoms. 4, quit smoking: smoking can increase the risk of SLE, and the disease activity index of SLE patients who smoke is also higher, so patients should quit smoking as soon as possible. Studies have found that the efficacy of prednisone on smoking patients is poor. 5. Vaccines: We recommend that patients receive some vaccinations prior to immunosuppressive therapy. Although vaccination was previously thought to worsen SLE disease, the influenza virus vaccine and pneumococcal vaccine are safe. Studies have found that patients with SLE produce lower titers of protective antibodies after vaccination than normal, which may be associated with ongoing use of glucocorticoids and immunosuppression. Quadrivalent anti-human papillomavirus (HPV) vaccines have been shown to be safe in patients with stable SLE and do not increase the rate of disease recurrence. The safety of hepatitis B virus vaccine in patients with SLE remains to be demonstrated. 6. Treatment of comorbidities: Atherosclerotic heart disease, pulmonary hypertension, anti-cardiolipin syndrome and severe osteoporosis can increase mortality in SLE patients, so timely screening and aggressive treatment can effectively improve survival rates. SLE patients with combined tumors can choose radiation therapy, but many studies have found that ionizing radiation therapy can bring more toxic side effects for SLE patients, especially those with combined systemic sclerosis. 7. Drugs to be avoided: Sulfonamide antibiotics can worsen the disease, so they should be avoided. Conversely, drugs that induce lupus have been shown not to worsen the disease, such as procainamide and hydrazidiazide, with the exception of mirex tetracycline.