Argon helium knife is minimally invasive treatment, bleeding is also less. 5 cm lesions are generally frozen 7 cm in diameter, basically can achieve the effect of surgical excision, but larger and irregular lesions, “cold cut” effect is not as complete as surgery. Therefore, if you can operate, you should do so. For those who do not have the conditions for surgical resection, argon helium knife has unique features. First of all, it is effective and no tumor dies wherever it is frozen. Secondly, it is a physical treatment without any side effects. In addition, it has a short treatment period, which is usually finished in one treatment, and patients can recover quickly and be discharged from the hospital after 2-3 days of observation, so there are less non-therapeutic expenses. Ar-He knife is not really a scalpel, it is just a hollow stainless steel needle. However, this small steel needle can save some advanced cancer patients who have been sentenced to death, especially those who have failed radiotherapy, lost the opportunity for surgery or do not want to operate. “When argon gas is released rapidly at the tip of the needle, it can freeze the diseased tissue to -120℃~-170℃ within ten seconds; when helium gas is released rapidly at the tip of the needle, it will produce rapid rewarming and warming, which will quickly thaw the ice ball and eliminate the tumor. Moreover, the speed of cooling and warming, time and the size and shape of the ice ball can be precisely set and controlled. In addition, the method can rapidly reduce the tumor load. Tumors less than 4 cm in diameter can reduce the load by more than 95%-100%, and tumors larger than 5 cm in diameter can reduce the load by more than 90%, and smaller tumors can achieve radical effect and prolong the survival of patients. Moreover, argon helium knife does not have the side effects associated with chemotherapy and radiotherapy. Currently, this technology has been used in more than 100 hospitals in China for more than 10 years and is a mature medical technology. Since this technology only freezes and heats the tumor at the tip of the knife, it causes less damage to the patient, less bleeding, fewer complications, faster recovery, and can be repeated, or combined with chemotherapy, radiotherapy or surgical therapy.