Diabetic pruritus may be related to high blood sugar, neurodermatitis, urticaria, eczema, insect bite dermatitis, etc. It is recommended to consult a doctor. The most common cause of systemic pruritus is dry skin, others such as neuropsychiatric factors (e.g., various neurological dysfunctions or organic lesions as well as emotional tension, anxiety, fear, etc.), systemic diseases (e.g., uremia, obstructive hepatobiliary diseases, hyper- or hypothyroidism, diabetes mellitus, desiccation syndromes, dermatomyositis, lymphomas, leukemias, and other malignant neoplasms, etc.). Generalized itching can be caused by pregnancy, medications or foods, climatic changes (e.g., temperature, humidity), work and living environments, lifestyle habits (e.g., excessively alkaline soaps, cleansing skin care cosmetics), and clothing worn close to the body. When diabetic patients with itchy skin should be treated under a doctor’s visit, active blood sugar control, and symptomatic treatment for the cause of itching.