There are more types of hypoglycemic drugs that can be taken for diabetes, mainly insulinotropic secretagogues (sulfonylureas and glinides), bisphosphonates, thiazolidinediones, alpha-glucosidase inhibitors, dipeptidyl peptidase-4 inhibitors, and sodium-glucose cotransporter protein 2 inhibitors, and so on. 1. Sulfonylureas are commonly used as glimepiride, gliquidone and gliclazide. Glimepiride is the drug with the strongest hypoglycemic effect. Gliquidone is suitable for patients with diabetes combined with renal impairment. Gliclazide can reduce platelet aggregation and delay the occurrence of complications. 2. Glargine such as Repaglinide is often used for postprandial hyperglycemia. 3. Metformin is the most widely used drug in diabetes mellitus, which is the first line of diabetes mellitus. It is forbidden for patients with liver and kidney insufficiency, high fever, chronic gastrointestinal disease, and so on. 4. Thiazolidinediones, such as rosiglitazone, are suitable for patients with obvious insulin resistance. Severe heart failure, active liver disease and other patients are prohibited. 5. α-glucosidase inhibitors such as acarbose, applicable to postprandial hyperglycemia, liver and kidney insufficiency patients are prohibited. 6. Dipeptidyl peptidase-4 inhibitors, such as saxagliptin, can be used alone, and is prohibited in people with allergic reactions and pregnant women and children. 7. Sodium-glucose cotransporter protein 2 inhibitors, such as dagliflozin, can also be used alone, but is contraindicated in patients with renal insufficiency. Oral hypoglycemic agents are contraindicated in children, pregnant and lactating women. What kind of hypoglycemic drugs to use, the doctor according to the condition to choose, the use of drugs should be strictly comply with the doctor’s instructions, if any discomfort in time to consult the doctor.