Secondary prevention is the main focus of medication for post-thrombotic cerebral thrombosis, which refers to cerebral thrombosis with symptoms of neurological deficits after more than 6 months of treatment. No matter what medication is used, the patient’s symptoms will not improve again, so only symptomatic treatment and secondary prevention are the main focus. Secondary prophylaxis includes antiplatelet aggregation treatment with aspirin or clopidogrel. Patients without gastric disorders or gastric discomfort can use aspirin, and those who cannot tolerate aspirin with gastric discomfort can consider clopidogrel. Patients with atherosclerotic plaque formation or vascular stenosis are treated with atorvastatin or resulvastatin at the same time. Patients with hypertension, diabetes mellitus and hyperlipidemia are treated with antihypertensive, hypoglycemic and lipid-lowering drugs. If the patient has cerebral thrombosis sequelae leading to limb stiffness and difficulty in movement, he can take baclofen or tizanidine to reduce muscle tone.