The consensus is that “ventricular septal defect (VSD) is the most common form of congenital heart disease, accounting for approximately 20% of all congenital heart diseases. At present, there are two main treatment methods: one is surgical repair with the assistance of extracorporeal circulation (CPB), and the other is percutaneous catheter interventional closure. In recent years, scholars at home and abroad have explored the technique of minimally invasive transthoracic occlusion of VSD under the guidance of ultrasound in the esophagus with the application of a modified occluder and delivery system by integrating traditional surgical techniques and the technical features of cardiac catheter intervention. This technique avoids the trauma and potential complications of extracorporeal circulation surgery on the one hand, and radiological radiation and age and weight restrictions of infant patients on the other. According to incomplete statistics, more than 5000 patients with ventricular septum have been successfully cured by this procedure in China, and our scholars have accumulated considerable experience, and the technique is rapidly being promoted and applied. Indications: (1) age usually R3 months old; (2) simple perimembranous VSD with hemodynamic abnormalities, VSD diameter 4-8 mm for those within 1 year; (3) simple myocardial VSD with hemodynamic abnormalities, 3 mm diameter and multiple myocardial VSDs; (4) sub-stem VSD without combined obvious aortic valve prolapse, VSD diameter 6 mm for those within 1 year; (5) post-surgical residual shunt; (6) myocardial infarction or post-traumatic ventricular septal perforation. Contraindications: (1) poorly aligned VSD; (2) postseptal atrioventricular access VSD; (3) combined with significant aortic valve prolapse with moderate or greater aortic regurgitation; (4) infective endocarditis with intracavitary bulges; (5) combined with other cardiovascular malformations that require simultaneous CPB surgical correction, but does not include complex malformations with combined VSDs that require the use of this technique to shorten CPB and blocking time, etc.” More than a dozen cases have been successfully performed with this technique, ranging in age from 6 months to 31 years, with a minimum weight of 6 kg, and this includes patients with ventricular defects in all locations as well as post-surgical residual shunts. The longest follow-up of this group of patients is currently close to one year, with satisfactory results.