Patients who are applying warfarin please see. 1. Warfarin is generally required for life. Suspend only if the International Normalized Ratio (INR) shows anticoagulation overdose. 2.When discharged from the hospital, take warfarin according to the recommended dose in the discharge summary and start blood tests for INR after 1 week of taking this dose. 3. The International Normalized Ratio (INR) was measured by blood test and the dosage of warfarin (2.5 mg per tablet) was adjusted according to the test results (INR) to maintain the INR of the patient between 2.0-3.0 (normal INR is 0.8-1.2). The INR value and the dose of medication taken are also recorded for each blood test so that the dose of medication can be adjusted. (1) When the INR is between 2.0 and 3.0, indicating that the previous dose of the drug is probably appropriate, continue to maintain the previous warfarin dose. (2) When the INR is <2.0< span="">, this indicates that the previous daily dose of anticoagulant medication is not sufficient and should be increased by 1/4 tablet (0.625 mg) from the previous medication and the INR should be checked after two days. (3) When the INR is >3.0, this indicates that the previous daily dose of medication may be slightly higher and should be reduced by 1/4 tablet (0.625 mg) from the previous dose of medication and the INR should be checked after two days. Also, monitor renal function and electrolytes or consult your physician. (4) When INR>3.5, it means that the previous daily dose of anticoagulant is too high, stop using “warfarin” on the same day, go to the hospital for INR test the next day, and suggest to follow up with the cardiology clinic to adjust the dose. 4, the time interval of the discharge test: after discharge from the hospital according to the doctor’s orders to review, according to the above method of adjustment, when the INR value is stable at 2.0-3.0, extend the interval, every 1 week to check. If it is stable, it can be checked once a month. Thereafter, if it continues to be stable, you can consult your physician to increase the examination interval to once every 2-3 months as appropriate. ”Stable” means two to four consecutive INR test results between 2.0-3.0, no need to increase or decrease the oral dose of “warfarin”. 5, warfarin can interact with many foods, to maintain a relatively stable dietary structure. Because vitamin K-rich food groups, such as animal liver, green leafy vegetables (spinach, celery, cabbage, lettuce, kale, asparagus, beans, broccoli, cauliflower, peas, etc.), soy milk, soybean oil, olive oil, green tea, etc. can reduce the anticoagulant effect, should avoid the intake of large amounts of these foods. Other foods such as garlic, ginger, dry celery, papaya, fenugreek, and grapefruit juice can enhance the anticoagulant effect of warfarin. Many drugs can affect the anticoagulant effect of warfarin, so care should be taken to avoid co-administration, and when co-administration is necessary, care should be taken to monitor and adjust the dose if necessary. The following drugs are commonly used to enhance the anticoagulant effect of warfarin: large amounts of alcohol, amiodarone, cimetidine, fluconazole, isoniazid (600 mg/d), metronidazole, miconazole, itraconazole, omeprazole, NSAIDs, propafenone, propranolol, lipid-lowering drugs (simvastatin, etc.), spectral antimicrobials (cefoperazone, cefamandole, quinolones, etc.), sulfonamides, macrolide antibiotics , allopurinol, heparin, etc., herbal medicines (Salvia, Angelica, Ginkgo preparations, Huang Lian, Huang Bai, garlic, etc.). The following drugs reduce the anticoagulant effect of warfarin: phenobarbital, grumet, methimazole, propylthiouracil, carbamazepine, rifampin, vitamin K, ribavirin, oral contraceptives and estrogen, herbs (ginseng, American ginseng and St. John’s wort, etc.). When you visit the doctor for other diseases, you should inform the doctor that you are taking anticoagulants, and it is better to increase the frequency of INR testing when you take other drugs for other diseases. 6, too high INR is easy to bleed, too low is easy to cause thrombosis, so patients should identify signs and symptoms of bleeding such as gum bleeding, skin or bulbar conjunctiva bruising, nasal bleeding, vomiting or hemoptysis, black stool, hematuria, excessive menstrual flow (female), etc.; also identify signs and symptoms of thromboembolism such as chest pain, abdominal pain, dizziness, numbness of limbs, limited movement, etc. If there are complications such as bleeding or embolism after discharge, you need to go to the hospital for timely treatment, and discharge from the hospital for regular outpatient review. 7. If you encounter any problems related to anticoagulation therapy, you can ask the cardiologist.