The signs of lipoma cancer are mainly the sudden abnormal enlargement, increase, pain, color change, local skin temperature increase, fever and wasting in a relatively short period of time. Lipoma is generally a soft lump formed by fat cells gathering on the skin surface, and the chance of malignant transformation is generally very low. However, if a long-term stable lipoma suddenly appears to harden, become bigger, have unclear boundaries, increase in size, have pain, change in skin color or ulcerate within a short period of time, then the condition may deteriorate. In addition, if the patient has fever, emaciation, loss of appetite, excessive sweating, anemia, fatigue and other malignant symptoms without obvious causes, it also suggests the possibility of cancer metastasis. It is necessary to go to hospital for examination and diagnosis in time. When abnormal changes occur in lipoma, patients should go to hospital for examination and diagnosis in time, so as to clarify the cause of the disease as early as possible and carry out active treatment.