21-year-old Zhang was originally a beautiful northeastern girl, but all this quietly changed three years ago. Originally a slim figure, the face of her become hands and feet, thick lips, skin darkened and rough. This can be scared Zhang’s mother, rushed to take Zhang around to seek medical treatment. After a series of examinations, it was found that Xiao Zhang’s head grew a 31mm*26mm*33mm tumor, which was located in the pituitary gland, leading to the excessive secretion of growth hormone, which caused a series of changes in Xiao Zhang’s appearance. Xiao Zhang and his mother finally chose to undergo transnasal endoscopic pituitary tumor resection in our department after searching for information on the Internet and consulting with doctors and friends. This minimally invasive surgery not only has smaller wounds, faster recovery and fewer complications. It also preserves a head of dark hair compared to open heart surgery, which is more acceptable to patients.