Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with an incidence of only 1:14,000, first reported by Gascoyens in 1860 and further described and named BRBNS by Bean in 1958, hence the name Bean syndrome. About 250 cases have been reported worldwide, mostly starting in adolescence, while cases in adults and younger children are rare. So how to check for this disease? The disease is usually characterized by multiple hemangiomas of the skin and gastrointestinal tract. Skin hemangiomas are almost 100% likely to be blue or purple in color, usually 1-2 cm in diameter, ranging from a few to hundreds in number, mostly on the trunk and extremities, and almost all patients have skin lesions that are found shortly after birth and increase in size with age, spreading even to subcutaneous tissues including muscles, bones and joints. Gastrointestinal angiomas are most common in the small intestine, followed by the colon and stomach. In addition, hemangiomas can be found in the nasopharynx, abdomen, mesentery, liver, lungs, penile head, eyes, and central nervous system. In the early stages, patients may present with only cutaneous hemangiomas and no other symptoms. In later stages, the hemangioma may increase in size and become complicated by rupture and bleeding or compression symptoms, usually acute or chronic bleeding from the gastrointestinal tract, or atypical symptoms such as hemoptysis, hematuria, and abdominal pain, which are related to the organs involved in the hemangioma. The number and size of the tumors increase with age and do not shrink on their own.