For people with Parkinson’s disease, every step is incredibly difficult, and it is common to describe the life of a Parkinson’s patient as difficult. The attack of Parkinson’s disease belongs to an exceptionally dangerous thing, many Parkinson’s disease patients will also have the switch phenomenon, so what exactly is the switch phenomenon of Parkinson’s disease? The switch phenomenon refers to the phenomenon of fluctuating drug effects in Parkinson’s disease patients after long-term application of levodopa drugs, a side effect produced by this type of drugs. “Off” is mainly manifested by the sudden appearance of limb stiffness, movement can not, like a power failure, such as walking suddenly can not take steps, as if wearing a shackle on the feet of the lead hammer, difficult to move. At the time of “opening”, despite the fact that no treatment was added, the activity was suddenly normal, the stiffness of the limbs disappeared, and the limbs could move freely. This is a relatively common and intractable complication of late levodopa therapy, and its control mechanism is not well understood. It may be that the receptor response to changes in dopamine levels produces sharp fluctuations (hypersensitive state). Symptoms may be improved with the use of dopamine receptor agonists, propargylamphetamine (Siginine). Prolonged use of a single therapy or a single prescription is often associated with side effects such as the “on-off” phenomenon. Therefore, even if a patient has been diagnosed, he/she should periodically adjust his/her treatment plan with a specialist, who can alleviate the symptoms according to the principle of ‘minimum dose, optimal effect, long duration, not long lasting effect’ based on the type and severity of the symptoms and the state of impaired functioning of the patient’s age. At present, with the continuous development of technology, medical standards continue to improve, the emergence of brain pacemaker surgery, has received a great response, the results achieved are very significant, is currently internationally recognized as a good method of treatment of Parkinson’s disease. Surgery can lengthen the time of “on”, shorten the time of “off”, moderate the sharp fluctuation of “on-off”, eliminate involuntary movement and “end-of-dose” deterioration effect. end-of-dose” deterioration effect. Therefore, the combination of pacemaker surgery and medication can achieve a better therapeutic effect and improve the quality of life of patients.