The prevalence of sub-health in Beijing, Shanghai, Tianjin and other cities in China is as high as 70%, and the causes are still unclear, among which the sub-health problem of brain workers is more prominent. 1.Subhealth distribution of brain workers Subhealth refers to some functional changes without organic lesions. It is the transitional stage between human health and disease. Although physiologically and psychologically there is no organic disease, subjectively there are many uncomfortable symptom expressions and psychological experiences. There are many causes of subhealth, such as energy and physical exhaustion caused by overexertion, natural aging of the human body, discomfort during the pre-cardiovascular and other chronic diseases, recovery period and post-surgery rehabilitation period, and the low point of the human biological cycle. Sub-health can be seen in people of all ages and different occupations, among which brain workers (white-collar workers) are the most prevalent group of sub-health. According to a survey conducted by the Chinese Academy of Sciences, the average life expectancy of intellectuals in China is only 58 years, which is about 10 years lower than the national average life expectancy, and many of them die young and overworked. At present, there are more studies on chronic fatigue syndrome abroad, which are considered to be related to social environment factors, heart factors, high workload and tension, etc. In the analysis of subhealth distribution and risk factors by Pang Jing and others, mental tension, heavy workload and teachers are important morbidity factors, and in the study on the measurement and analysis of subhealth status of university teachers by Qiao Xiaosu and others, insufficient cerebral blood supply, malignant fatigue and neurasthenia account for a fairly One of the data showed that the lower the seniority of teachers, the worse their subhealth status, probably because they are under greater pressure from family, promotion, teaching, etc.]. The incidence of subhealth among white-collar workers is basically the same in Shanghai or Beijing, in the south or in the north, with different living environments, dietary habits and local climates. 2.Characteristics of sub-health of brain workers 2.1 Symptom characteristics The symptoms of sub-health can be seen in all systems of the body, but they are concentrated in the central nervous system, which consumes the most oxygen and has the least oxygen reserve, such as headache and dizziness, lack of concentration, distraction, insomnia and dreaminess, drowsiness, memory loss, and reduced work ability. The weight of the brain accounts for 2% to 3% of the body weight, but the oxygen consumption of the brain under physiological condition accounts for 20% of the total oxygen demand of the whole body, so the brain is the largest oxygen-consuming organ of the whole body, and the reserve of brain oxygen and glucose is very little, and it needs continuous blood supply, so the brain is most sensitive to hypoxia, once there is slight hypoxia, the brain symptoms appear the earliest, if the hypoxia can not be corrected in time, only gradually other system discomfort will appear If hypoxia cannot be corrected in time, only then will other system discomforts gradually appear, such as chest tightness and breathlessness, panic and shortness of breath, weakness, no appetite, etc. 2.2 Causes of hypoxia Five causes can cause hypoxia, (1) hypoxia: refers to the hypoxia caused by insufficient oxygen in the inhaled air, such as reduced atmospheric pressure on cloudy days; highland areas, poorly ventilated rooms, offices and special working environments; bronchitis, emphysema, pulmonary heart disease, bronchial asthma, lung infections and other respiratory diseases that cause alveolar ventilation and perfusion ratio disorders, alveolar wall diffusion function decline (2) Hematologic hypoxia: Insufficient alveolar ventilation or obstruction of large and small airways due to drowning, self-hanging, asphyxia, etc. (2) Hematologic hypoxia: refers to the hypoxia caused by the decrease of blood transport oxygen capacity. Such as anemia caused by various reasons, acute and chronic blood loss, carbon monoxide and other kinds of harmful gas poisoning, nitrite poisoning, etc. (3) Circulatory hypoxia: refers to the hypoxia caused by the obstruction or reduction of blood circulation. Such as clinically common coronary heart disease, arrhythmia, heart failure, shock, cerebral infarction, cerebral blood supply deficiency, vasculitis, etc. (4) Tissue toxic hypoxia: refers to the hypoxia caused by the inability of oxygen to penetrate into the tissue from capillaries or the inability of tissue cells to use oxygen effectively. Such as cyanide poisoning and other kinds of harmful gas poisoning, edema, etc. (5) Oxygen consumption increase hypoxia: refers to the relative hypoxia caused by an obvious increase in oxygen consumption of the body in a short period of time. Such as heavy exercise, high-intensity labor, pregnant women, brain workers, students before examinations, etc. Among the above five categories of hypoxic causes, relative hypoxia caused by increased oxygen consumption is one of the main causes of hypoxia in brain workers, and other causes of hypoxia are often masked by underlying diseases. There are several reasons to support that hypoxia is one of the main causes of suboptosis: (1) Suboptosis occurs in brain workers. (2) Suboptimal health mainly manifests as neurological discomfort with the greatest oxygen consumption and the least oxygen reserve. (3) The treatment idea of improving hypoxia, namely hyperbaric oxygen therapy, is effective. 3, the pathogenesis of subhealth of brain workers In the past, many materials mentioned that stress and mental tension are the common causes of subhealth, but few people have investigated why stress and mental tension can cause subhealth. Oxygen is a necessary substance in the metabolic process of the body, and is the basis for the pathogenesis of many diseases, and the hypoxia-inducible factor can induce apoptosis when there is continuous hypoxia. When the body is in a state of hypoxia, energy (ATP) production will be impaired, directly affecting the sodium-potassium-ATPase (pump) function of the cell membrane, so that the intracellular sodium ions can not be transferred to the extracellular in a timely manner, thus causing intracellular edema, while the extracellular potassium ions can not be transported to the cell in a timely manner, resulting in a decrease in intracellular potassium concentration, affecting the excitability and conductivity of the cell, in addition to affecting the calcium channels of the cell membrane, increased free radicals, decreased mitochondrial function and even swelling. The swelling of mitochondria directly affects oxidative phosphorylation, which further reduces the production of ATP (energy). Studies have shown that hypoxia can lead to cell membrane damage, reduced cell viability, and even nuclear consolidation, detachment, and apoptosis. In ischemia-reperfusion injury there is damage to mitochondria, mainly affecting calcium channels, and as a result of this ischemia all human physiological and social activities depend on a continuous supply o energy, and this energy supply o deprivation occurs in different tissues causing the corresponding discomfort manifestations [6]. Studies have found increased blood viscosity in subnormal individuals, and increased blood viscosity affects the oxygen delivery capacity of the blood. Hypoxia adversely affects the electrical activity of the brain in rats, where hypoxia mainly affects cell membrane potential, synthesis of mediators, synthesis of ATP, acid-base metabolism of cells, calcium channels of cells, release of lysosomes, etc. If you are a brain worker, such as computer workers, students, teachers, research workers, office workers, etc., the brain is in high-speed operation for a long time, brain oxygen consumption will be much higher than 20%, while your cardiopulmonary function has not changed, when more than the physiological regulation limit, the accumulation of months will cause the body due to increased oxygen consumption caused by relative hypoxia. In a survey on the subhealth of female university staff, Shanshan Yang analyzed and concluded that the incidence of subhealth is higher in those who work as teachers than in those with other job nature, and high stress is the main factor leading to subhealth, including work stress, mental condition, emotional condition and environmental factors [7]. The analysis of brain function in 168 cases of insomnia concluded that there is a tendency of brain ischemia and hypoxia with excessive excitation of the brain, which consumes a lot of energy. 4 , Thinking about subhealth treatment for brain workers Li Suzhi reported that sleep disorders and plateau hypoxia are highly correlated, and the key to treatment is how to improve hypoxia as soon as possible. There are many methods to improve hypoxia, such as applying vasodilating drugs, reducing local oxygen consumption, increasing heart rate and pulmonary ventilation, increasing the number of red blood cells through self-regulation, etc. Hyperbaric oxygen is to directly increase the oxygen content in blood to improve hypoxia, rapidly, in sufficient quantity and efficient. 4.1 Hyperbaric oxygen therapy Poor sleep quality is a common symptom of sub-healthy people, early physical or energy overdraft is likely to lead to slight hypoxia, when slight hypoxia, people show excitement, the result of excitement will directly affect sleep, the oxygen consumption in the waking state is much higher than that in the sleeping state, so poor sleep quality in turn will increase oxygen consumption, further aggravate hypoxia, and finally form insomnia → insomnia The vicious circle of insomnia → oxygen deprivation → insomnia is difficult to get out of this vicious circle by self-regulation, so how to improve oxygen deprivation quickly and effectively is the key to the treatment of these patients. Hyperbaric oxygen can rapidly increase the oxygen content in the body. The partial pressure of oxygen in plain air is 159 mmHg, and the partial pressure of oxygen inhaled by conventional hyperbaric oxygen therapy (0.2Mpa) is 1520 mmHg, and the oxygen content in the body increases accordingly during the process of oxygen inhalation. (2) It increased the effective diffusion distance of oxygen, so that the parts far from capillaries can also get sufficient oxygen supply, and the diffusion distance of oxygen can be increased from 30um to 100um at 0.3Mpa. (3) It promoted the recovery of sodium-potassium-pump function of cell membrane, which is conducive to the recovery of intracellular edema. (4) It promotes the metabolism of the body and facilitates energy production. (5) It has a regulatory effect on the immune system and facilitates the mobilization of the body’s self-regulatory potential. Shi Yan et al. reported that hyperbaric oxygen can effectively treat neurasthenia (15), and Liao Shongyi et al. reported that hyperbaric oxygen can effectively treat chronic fatigue syndrome, which are all diseases belonging to the category of subhealth (16). 4.2 Reasonable arrangement of aerobic exercise Light sports is the symptomatic treatment of subhealth, aerobic exercise refers to the exercise based on aerobic metabolism, which requires a certain duration and a certain intensity, generally once a day, each exercise for about 1 hour, the intensity control can self-monitor heart rate, you think the most exertion when the heart rate increases by 30%-50% is better, reasonable aerobic exercise Can fully mobilize the body’s regulatory potential, the discharge of metabolic waste in the body, with the deepening of breathing to speed up take away the turbid air in the lungs, thus increasing the cardiorespiratory function. 4.2 Avoid excessive fatigue Everyone according to their own work nature, work environment and previous work feelings, after a certain time (such as 1 hour) should take the initiative to go outside or air circulation place to rest for a few minutes or ten minutes, once the excessive fatigue will need several times or even dozens of times of time to adjust to a normal state. Summary: Hypoxia is one of the main causes of subhealth in brain workers, and hyperbaric oxygen has special efficacy in promoting the recovery of subhealth. Compared with traditional Chinese medicine, hyperbaric oxygen therapy focuses on the treatment of the former and the latter on the regulation of the latter, combining regulation and treatment, reasonable treatment, prevention-oriented, and treatment of symptoms. In the initial stage, hyperbaric oxygen therapy is recommended for subhealth patients, and after the symptoms are basically relieved, Chinese medicine or self-regulation therapy can be used.