Recently, the functional neurosurgery department of Brain Hospital successfully performed hemispherectomy for two patients with intractable epilepsy, and the postoperative follow-up showed satisfactory results and effective seizure control. It is reported that this surgical treatment for intractable epilepsy is the first of its kind in the province. The patient, Li XX, had a history of head trauma when he was young and developed right-sided limb movement disorder after the injury. Since the age of six, he had seizures, mainly generalized tonic-clonic seizures, which were characterized by loss of consciousness, tonic jerking of the limbs and blue lips. The seizures were frequent and the effect of various antiepileptic drugs was not effective. He had a 13-year history of seizures at the time of admission. Patient Fu XX was found to have poor muscle strength in the right limb by his parents at 6 months of age. At the age of one year, he started to have seizures, mainly generalized tonic clonic seizures, with frequent seizures. He had been seen at several hospitals and took various antiepileptic drugs, but his condition was still not effectively controlled, and he had a 32-year history of seizures at the time of admission. Long-term seizure history seriously affected the patient’s quality of life and brought great obstacles to their employment and marriage, etc. The patient and his family had a strong desire to cure the disease through surgery. Based on the patient’s medical history, cranial MRI and video EEG results, and with reference to domestic and international information, Dr. Jin Peng, Dr. Sun Peng and Dr. Yang Xinsheng of the Department of Functional Neurosurgery decided to perform a hemispherectomy for the patient. Hemispherectomy is mainly used to treat patients with intractable epilepsy secondary to diffuse lesions in the unilateral cerebral hemispheres. Data show that the antiepileptic effect of hemispherectomy is very positive, with a postoperative efficiency of over 90% and up to 80% for those whose seizures disappear. Although both patients in our hospital underwent left hemispherectomy, the functions of language and physical activities were not significantly affected, and the preoperative functional status was preserved, while the seizures were effectively controlled, and no seizures occurred again in the postoperative follow-up. The development of cerebral hemispherectomy has further expanded the scope of functional neurosurgery treatment in our hospital, and has enabled our epilepsy surgery to leap to a new level of treatment.