Palmoplantar pustulosis is a chronic recurrent skin disease. Most scholars now consider the disease to be a limited pustular psoriasis, while others consider it to be a pustular bacterial rash. The etiology of this disease is unknown and may be related to infection and metal allergy. Pregnancy, trauma, endocrine disease and reaction to various local treatments can be used as stimulating factors to stimulate the disease. Clinical characteristics 1, this disease is mostly seen in middle-aged women. It mainly occurs in the palm and metatarsal, characterized by clusters of aseptic intraepidermal pustules. 2, the rash often occurs in the central part of the palm and metatarsal and metacarpal size interspace, can gradually spread to the palm and metatarsal and its side, including the flexure surface of the fingers and toes. It is often symmetrically distributed. 3, the primary damage for the batch of needle tip to rice grain size deep in the sex pustules, gradually increased, the scope of expansion, dry after the appearance of thicker scales and brownish-yellow crust, lesions recurring up to several decades. 4, self-conscious burning sensation, pain. Bacterial examination of pus is negative.