In clinical practice, the difference between pancreatitis and appendicitis lies in the location of abdominal pain. Patients with biliary pancreatitis may have pain in the right upper abdomen, but it gradually shifts to the left side, and when the lesion involves the whole pancreas, the pain is wider and radiates to the waist and back in a band; whereas patients with acute appendicitis usually have metastatic pain in the right lower abdomen. In patients with acute appendicitis, the pain is usually metastatic in the right lower abdomen and the location of the pain is more fixed. In addition, some of the similarities between the two are that they both have gastrointestinal symptoms, such as bloating, nausea, vomiting, etc. However, the symptoms of pancreatitis are very severe, while those of appendicitis are usually mild. In addition, if the patient’s condition becomes severe, both will show signs of peritonitis; however, the signs of peritonitis in pancreatitis are more severe, while the signs of peritonitis in appendicitis are less severe.