Enzyme itself is an enzyme, which is not harmful to human body. Enzyme is a natural ingredient and has the function of helping metabolism. However, most enzymes are made with added sugar, anthraquinones and bacteria, which may cause harm to human body. 1. High blood sugar: Enzyme products often contain a lot of added sugar, which may cause elevated blood sugar. Diabetic patients should be careful with enzyme products. 2. Intestinal blackening: Many enzyme products usually add anthraquinones to increase the metabolic effect, which may lead to blackening of the intestinal tract and colorectal melanosis after long-term use. 3. Long-term consumption of such enzyme products may lead to bacterial infection, resulting in intestinal flora imbalance and acute and chronic enteritis. In general, we can promote intestinal peristalsis, prevent and relieve constipation by drinking enough water, doing appropriate activities, and supplementing dietary fiber and probiotics, and patients with long-term constipation should undergo colonoscopy and other tests in time for reasonable treatment. At present, enzyme products are of different quality and should be purchased with caution. Self-made enzymes do not control the growth of harmful bacteria and produce ethanol and methanol, so from the safety point of view, it is not recommended to drink them.