Malignant body cavity effusion mainly includes thoracic, abdominal and pericardial effusion, which is a common complication of advanced tumors and seriously affects the physical and mental health of patients. The use of traditional methods to repeatedly pump out the effusion will only cause the patient to lose a large amount of protein, electrolytes and other components, and the survival period is usually 3-4 months, which has long troubled the majority of medical workers. Thermal perfusion chemotherapy is a new therapy that combines chemotherapy and thermotherapy to treat tumors. Its principle is to use physical energy to heat the chemotherapeutic drugs with good thermal effect and infuse them into the tumor site to raise the temperature of tumor tissue to the effective treatment temperature and maintain it for a certain period of time, so as to achieve the therapeutic purpose of causing apoptosis of tumor cells without damaging normal tissues by using the difference of temperature tolerance ability between normal tissues and tumor cells. Thermal perfusion chemotherapy makes the organic complementary effect between thermal therapy and chemotherapy perfusion drugs, and increases the sensitivity of patients to chemotherapy. It can kill malignant tumor cells more effectively, improve patients’ survival quality and prolong their lives, and at the same time reduce the side effects caused by radiotherapy and chemotherapy, so it is called “green therapy” by the international medical community. Heat perfusion chemotherapy mechanism 1.High temperature 42℃～43℃, causing cell damage. Tumor tissues are more sensitive to heat than normal tissues, so heating has a direct toxic killing effect on cancer cells, and maintaining the temperature above 42℃ for 50-60 minutes has a significant inactivation effect on malignant tumors. 2.Improve the drug concentration of local tumor tissues, and the high concentration of chemotherapy drugs can overcome the drug resistance of tumor cells, so as to better play the anti-cancer effect. 3.Heating can improve the sensitivity of tumor cells to certain chemotherapeutic drugs, while the permeability of cells is enhanced and the microenvironment and pharmacokinetics of tumor cells are changed, which strengthens the effect of anti-cancer drugs. Warm liquid can increase the permeability of anti-cancer drugs, with direct penetration depth up to 5mm, which can enhance the cytotoxic effect of chemotherapy drugs and induce apoptosis of tumor cells, and also prevent tumor recurrence and improve the survival rate of patients. 4.The combined application of heating and chemotherapy has significantly enhanced the killing effect on cancer cells compared with the effect of heat therapy alone and chemotherapy alone. Indications 1.Respiratory system: lung cancer, pleural mesothelioma, cancerous pleural effusion. 2.Gastrointestinal system: stomach cancer, pancreatic cancer, liver cancer, gallbladder duct, cancer, intestinal cancer colon, rectum, and cancerous abdominal effusion. 3.Genitourinary system: perfusion chemotherapy of bladder cancer, advanced prostate cancer, ovarian cancer, cervical cancer, etc. abdominal metastasis. 4.Lymphatic system: thoracoabdominal infiltration of malignant lymphoma. 5.Other: breast cancer, various sarcomas leading to thoracic, abdominal and pelvic metastases. 6.Remedial treatment for incomplete intraoperative resection of abdominal tumors and prevention of postoperative tumor implantation and metastasis.