Pituitary tumor is a common primary brain tumor, accounting for 19% of surgically resected brain tumors. It is seen in all age groups, but increases with age, with the most frequent incidence between 30 and 60 years old. In recent years, with the development of diagnostic techniques such as MRI, its incidence has tended to increase. Patients with pituitary tumors present with two main symptoms: i. Endocrine disorders caused by the secretion of large amounts of hormones by pituitary tumor cells. Prolactinogenic (PRL) pituitary tumors: female patients experience menstrual disorders, amenorrhea, breast overflow, and infertility, while males experience decreased sexual function, breast development, and infertility. Growth hormone (GH) pituitary tumor: Patients develop facial changes, especially noticeable on the nose, lips, jaw and forehead, and wrinkles on the scalp; coarse deformation of hands and feet, sudden increase in shoe size, and joint pain, which may be treated as rheumatic or rheumatoid arthritis for a long time, leading to prolonged disease. In fact, the greatest danger of growth hormone pituitary tumors is that they cause intractable and difficult-to-control comorbidities such as diabetes, heart disease, apnea syndrome, and digestive tract tumors, which should be treated promptly. Adrenocorticotropic hormone (ACTH) pituitary tumor: Patients develop centripetal obesity, full-moon face, buffalo back, dilated capillaries, polycythemia, thin facial skin, frequent acne, purple skin lines, mostly in the lower abdomen, buttocks and thighs, emotional irritability and temper tantrums. It is often combined with hypertension, diabetes, electrolyte disorders, etc. Secondly, non-functional pituitary tumor cells do not secrete hormones, so there is no obvious performance when the tumor volume is small. When the tumor volume increases, it will compress the normal pituitary gland and the surrounding nerve structures. Hypopituitarism: Patients often start with fatigue and weakness, anorexia and nausea, and firstly consult internal medicine, gastroenterology and cardiology for treatment, but the effect is not good and the course of the disease is prolonged. Some patients are so ill that they can only be wheeled to the hospital on a flat cart. Visual impairment and visual field defects: The tumor is large in size and compresses the optic nerve. Pituitary tumor seriously endangers patients’ health and should be treated promptly. At present, the main treatment options for pituitary tumors are surgery, medication and radiation therapy. Although there are great developments in drug and radiation therapy, surgery is still the first choice or the main treatment for pituitary tumor treatment. We are equipped with internationally advanced and domestically leading technical equipment: high field strength intraoperative MRI system, BrainLab neuronavigation system, Leica surgical microscope, and German Storz endoscopy system. The pituitary tumor treatment group headed by Director Zhang Dajian is experienced in minimally invasive surgery for pituitary tumors. The transnasal butterfly approach for pituitary tumor surgery is safe, less traumatic, faster recovery, shorter operation time, and higher rate of complete tumor resection. Because the diagnosis, treatment plan selection, before and after surgery of pituitary tumor involves multiple disciplines such as neurosurgery, endocrinology, obstetrics and gynecology, ophthalmology, internal medicine, etc., we have set up a collaborative group of pituitary tumor that combines the treatment experience of various disciplines, so that our pituitary tumor treatment results reach the leading level in China.