Clinically, the gold standard for determining the benign or malignant nature of bile duct tumors is pathological biopsy, in addition, it can also be diagnosed by symptoms, as well as imaging, serology and other tests. 1. Pathologic biopsy. Pathological biopsy is the gold standard for determining the nature of tumor in clinic, which is performed by puncture or surgery on the lesion site. Although the process is invasive, it has the highest accuracy and diagnostic value. 2. Imaging examination. Enhanced CT, ultrasound and other examinations can roughly determine the size and location of the tumor, and can also initially help to determine the benign or malignant nature of the tumor. 3. serological examination: CA199 and other markers of digestive tract tumors can also indicate the benign or malignant nature of the tumor. 4. Symptoms. In addition to non-specific symptoms of bile duct tumor such as abdominal pain, abdominal mass, jaundice, etc., cancer is often accompanied by some specific symptoms such as chills, unexplained persistent low-grade fever, malaise, etc., which can also help diagnosis to a certain extent. It is suggested that those who suffer from bile duct tumor should seek medical treatment in time, and complete the relevant examinations under the guidance of doctors to clarify the nature of the tumor, so as to decide the next diagnosis and treatment plan.