It is caused by the infection of the prostate by virulent bacteria or other pathogens that grow and multiply rapidly. The main pathogen is Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, etc. The majority of these are single pathogen infections. The majority of them are single pathogenic infections. The route of infection is mostly bloodstream infection and retrograde infection through the urethra. (2) Retrograde infection via the urethra: Retrograde infection via the urethra may be the main route of prostate pathogen infection. There are a variety of risk factors for infection present: 1, frequent masturbation or sexual activity can make the urethra and prostate too frequently congested and edematous. 2, alcohol and spicy foods stimulate the urethra and prostate, causing congestion and vasodilation of prostate tissue, which facilitates the growth and spread of pathogens. 3, prostate fluid, semen or urine stagnation with the urethra, conducive to the growth and reproduction of urethral microorganisms and migration. Commonly seen in people who masturbate to stimulate holding back semen without ejaculation. 4, sexually transmitted diseases. 5, medical injury with a. 6, cold, overexertion resulting in lower resistance of the body. 2, histopathological changes: (1) Catarrhal prostatitis: infection spreads from the prostatic excretory duct to the glandular lumen, with increased congestion, edema and exudation. The luminal glandular epithelium is infiltrated with mild inflammatory cells, and the epithelium of the glandular ducts is hyperplastic and desquamated. (2) Follicular prostatitis: each follicular duct has epithelial detachment and pus cell infiltration , which can form pseudo-abscesses or small abscesses. The entire gland becomes soft and swollen with elasticity. (3) Substantial prostatitis: Inflammation spreads around the alveoli, eosinophilic cells infiltrate the interstitium, epithelial necrosis is shed, and the lumen of the gland is therefore not easily distinguishable. In about 1/2 cases, the abscess continues to expand and eventually penetrates into the urethra, perineum or rectum.