Ankylosing spondylitis is a chronic self-inflammatory disease that is currently incurable, but can be treated in a controlled manner to reduce its impact on life. Therefore, the severity of ankylosing spondylitis depends more on the treatment and care of the disease, and the more timely the treatment, the better the prognosis. The pathogenesis of ankylosing spondylitis is not yet clear, and it is mostly thought to be clinically related to genetics. I. Clinical manifestations: The main clinical manifestations are joint damage, such as sacroiliac joints, and pain in the hip, knee and ankle joints of the lower limbs, which may also cause spinal ankylosis and fibrosis. In the later stages of the disease, joint ankylosis and osteoporosis may occur, which may lead to fracture, and corresponding lesions may occur when the eyes, lungs and muscles are involved. Second, the treatment: 1, physical therapy: mainly including joint training treatment, or massage, ultrashort wave therapy and hydrotherapy, to help relieve local muscle tension, promote blood circulation, play a role in relieving the symptoms of discomfort; 2, drug therapy: the main use of non-steroidal anti-inflammatory drugs, such as ibuprofen, acetaminophen, celecoxib, etc.. Or anti-rheumatic drugs such as salbutamol, methotrexate, etc.; 3, surgical treatment: If the hip joint has serious lesions or serious deformities of the spine, you can choose to undergo spinal orthopedic surgery. The main treatment aim of this disease is to improve the quality of life of patients by controlling the inflammation and clinical symptoms and delaying the appearance of joint deformity as much as possible. The prognosis varies depending on the severity of the disease and the individual’s physical condition. If the disease is diagnosed early and treated properly, the prognosis is usually good and the impact on life and work can be reduced significantly. If the disease is not treated aggressively, it can lead to other joint damage and disability in severe cases.