Emotional and psychological factors are closely related to the occurrence, development and prognosis of breast cancer. Emotional and mental abnormalities are both the cause and the product of the pathology of breast cancer, and they are mutually causal. The treatment of regulating the emotions and strengthening the liver and spleen is the whole process of the disease. Chinese medicine believes that breast cancer belongs to the category of “accumulation” and emphasizes on endogenous factors, especially on internal injuries of the seven emotions. The medical practitioners of all generations believe that abnormal emotions are closely related to the occurrence of breast cancer. If the emotions are not in order, the liver will lose its control, which will lead to stagnation of Qi and blood; if the spleen is injured, it will not be able to transport and transform properly, and phlegm will grow inside; if the phlegm and stagnation of phlegm and stagnation of phlegm are intertwined in the breast, it will become breast rock. The formation of breast cancer is mainly due to the lack of good mood, internal deficiency of positive energy and dysfunction of internal organs, which leads to the entry of evil toxins (carcinogenic factors) and the formation of breast rocks over time. In the treatment of breast cancer, it is important to de-stress the liver and spleen and regulate the emotions. Fear of surgery and pain, fear of nausea and hair loss during chemotherapy, fear of death and recurrence of the disease often lead to a series of negative emotions. The main manifestations are worry, nervousness, impatience, pessimism, disappointment and other psychological disorders, and even light-hearted behavior. The liver is the organ that collects blood, and it is the main organ of drainage and yin and yang. The physiological characteristics of the liver are that it is the master of draining, and its physiological characteristics are that it is the master of ascending and active, which regulates the qi of the whole body and promotes the flow of blood and fluid, so that the qi and blood of the body are in harmony, the meridians are open, the functions of the internal organs are in harmony, and the mood is happy. Depression and anger injure the liver, which leads to a loss of health of the spleen, resulting in the pathological manifestation of “disharmony between liver and spleen”. As mentioned in the book of Surgery, “The nipples belong to the Liver meridian of the Foot, and the breasts belong to the Stomach meridian of the Foot,” which means that the breasts are closely related to the Liver meridian. According to Chinese medicine, the liver is the place where the human body regulates its emotions. The liver regulates the changes in human emotions through its influence on qi, blood and emotions. Therefore, the normal function of the liver is directly related to the physiological function of other organs of the body and the occurrence, development and regression of diseases. The treatment of depression should be based on draining the liver, nourishing the blood and regulating the qi flow, which can often achieve good results. It is widely used in the treatment of depression and anxiety and other emotional disorders. Emotional and spiritual factors are closely related to the prognosis of breast cancer. In Chinese medicine, the functional activities of the human body and its ability to resist external invasion and eliminate harmful factors are called “Zheng Qi”, including the immune function of the human body, which is an important internal factor in the occurrence of tumors. Changes in the function of immune system are positively correlated with the prognosis of tumor patients. Clinical studies have found that breast cancer patients who have undergone surgery, radiotherapy and chemotherapy and entered the recovery period have different degrees of psychological disorders, which not only seriously affect the quality of survival, but also have a negative impact on disease prognosis and regression. Among the factors affecting tumor recurrence and metastasis, immune response and hormones are the main ones at play, while negative emotional stimulation affects endocrine and immune systems, causing autonomic dysregulation, reducing patients’ autoimmunity and impairing immune (especially cellular immune) functions. The material basis of the relationship between emotions and health is closely related to NK cells (natural killer cells) in the body. It is a special lymphocyte lineage that can directly kill target cells and has anti-tumor and anti-infection immunomodulatory functions, and it shows a rapid effect. Clinical studies have shown that mental stress and emotional pessimism can reduce the immune function of NK cells, and people with low NK cell activity are prone to cancer or viral infections; while cancer patients with low NK cell activity are prone to metastasis or recurrence. The concept of recovery includes both the physical aspect, which refers to the cure and recovery of the disease, and the psychological aspect, which refers to the recovery of the mind and emotion. Abnormal emotional activities can contribute to the occurrence or deterioration of tumor, while positive emotional activities can prevent the occurrence of tumor or prolong the life of tumor patients. Breast cancer rehabilitation requires both physical and mental treatment, including not only physical rehabilitation and functional rehabilitation, but also psychological rehabilitation and social rehabilitation, in order to reduce the pain of advanced patients and improve their quality of life. Therefore, the relationship between emotional and mental factors and malignant tumor must be paid attention to.