Xiao Fang (a pseudonym), an 18-year-old girl from Hunan, unfortunately had pain in her thoracic back for 5 years at the time when she was looking forward to her life, such as the flower life, gradually worsened, each time the pain lasted about 20 seconds, the pain was so intense that she could only stop moving, and her hands covered her front and back. Magnetic resonance imaging (MRI) and CT examination suggested that a huge pyknotic mass, about 14×5 cm in size with irregular margins, was seen on the left side of the 4th-9th thoracic vertebrae, and its medial side extended through the intervertebral foramen to the spinal canal and connected to the spinal cord. Considering that the tumor was huge and the site was adjacent to the important large blood vessels (descending aorta) and spinal cord, the operation was very risky, and the blood vessels might be injured during the operation, leading to hemorrhage, which could be directly fatal. If the resection is not complete, the tumor may recur after the surgery; if the surgery is not performed, the tumor may continue to grow, the pain may continue to worsen, and in serious cases, the mass may compress the spinal cord and cause paralysis. Hearing the above, Fang and her parents understood how terrible Fang’s disease was, why the operation could not be done in general hospitals, and why there was a greater risk even in our hospital, and the family was sad, worried and concerned since then. After being hospitalized and undergoing pre-operative tests, it was discovered that Fang’s blood type was Rh-negative, the so-called “panda” blood type, which means that there is no D antigen on the surface of red blood cells, and more than 98% of Chinese Han Chinese are positive, with more negative minorities. The surgery was difficult and there might be a lot of bleeding, so blood preparation and transfusion were needed, and it was best to prepare the same type of blood for transfusion, but the stock of this type of blood in the blood station was very small and expensive, so it was decided to prepare autologous blood for Xiao Fang before the surgery. As the saying goes, “a stone from another mountain can be used to attack the jade”. Argon-helium knife is an argon-helium superconducting technology system successfully developed abroad in recent years, simulating space rocket guidance technology, introducing deep low temperature into the body, which can kill cancer cells directly and precisely, which is a new breakthrough in the history of cancer treatment. Its advantages include no or less bleeding, no toxicity to surrounding normal tissues and organs, minor damage, and can be repeatedly performed. On the basis of the successful experience of our spinal orthopedics department, Prof. Cai Kaican, Dr. Wu Hua, Dr. Zheng Minghui, and Prof. Wang Jixing of our spinal orthopedics department combined their efforts to perform argon helium knife assisted complete resection of the giant mediastinal tumor for Xiao Fang under general anesthesia in late November last year, with little intraoperative bleeding, significant freezing effect, and little damage to the surrounding tissues. The postoperative pathology suggested ganglion cell neuroma. After the operation, no sensory and motor disorders of the limbs were observed, and she was discharged from the hospital happily. In the case of huge mediastinal masses, the argon helium knife assisted cryopreservation technique brings the possibility of resection of huge masses and significantly reduces intraoperative bleeding, which is a blessing for similar patients when considering the complicated factors such as difficulty of surgical resection, high intraoperative bleeding and adjacent important organs.