Chemotherapy is the main treatment for advanced breast cancer, metastatic breast cancer and triple negative breast cancer, but chemotherapy is a “double-edged sword”, although it can treat tumors, it can also cause nausea, vomiting, hair loss, weakness, liver, kidney and heart function damage, blood cell reduction and other adverse phenomena. The main reason is that chemotherapy drugs kill cancer cells and harm normal cells at the same time. During chemotherapy, doctors need to closely observe patients’ chemotherapy-related toxic side effects and give timely treatment. Anti-emetic drugs are usually applied to avoid severe vomiting that leads to electrolyte disorders, and blood tests and liver, kidney and heart functions are also reviewed in a timely manner. We have given DC-CIK cellular immunotherapy to patients after chemotherapy, which has achieved good results in alleviating toxic side effects after chemotherapy and restoring patients’ normal immune status and blood cell levels. For patients, it is important to understand the discomfort reactions caused by chemotherapy during chemotherapy, maintain an optimistic and strong attitude, and actively cooperate with the doctor’s examination and treatment. The diet should be light, with appropriate supplementation of high quality protein, and any discomfort should be communicated to the doctor in time to avoid delaying the disease. The discomfort brought by chemotherapy is only temporary, and the patient can enjoy life again after the disease is in remission. Only when the doctor and the patient work together can we overcome the disease as soon as possible and promote the improvement of the disease.