This is the exchange I had with a patient who first used hydroxychloroquine sulfate after reading the instructions and finding so many side effects, especially in the eyes, and asking me questions. In fact, many of the drugs we use now to treat rheumatic diseases can be said to be used in excess of the scope of the drug, such as methotrexate, the instruction book is written to treat breast cancer, lorazepam written to treat enteritis, thalidomide is the treatment of pregnancy reactions caused by guinea pigs children after the drug was called off, azathioprine, sulfophosphamide are drugs for the treatment of tumors, Chinese medicine, for example, I myself love to use to treat dry syndrome of the Zongsheng pill. It’s just a medicine for sore throat, so more often than not we have to do a lot of explaining to the patient, and here’s a reply that may be able to help more of our friends. Patient’s question: Hello, doctor! The hydroxychloroquine sulfate tablets prescribed today have a lot of side effects, some of which are irreversible, do I need to worry? Because I’m a little scared to see the damage to my eyes. My answer: We have female patients that have been taking it while pregnant! Because this drug was changed excessively from primaquine, which is the main drug we used to use to fight malaria, and later used to treat lupus, and later used to treat many autoimmune diseases. Because of the side effects of primaquine, the instructions of chloroquine drugs have been used. When we first started to use this drug more than 20 years ago, we checked the fundus of the eyes every three months. However, we will remind the patient to do the relevant examination in some patients who have been using the drug for a long time. For some patients, although the ophthalmology does not suggest a problem, the patient does have uncomfortable eye symptoms, as long as the condition allows me to stop using the disease, after all, it is still safety first.