Patients with brain metastasis of small cell lung cancer can be treated with chemotherapy, radiotherapy and targeted therapy as prescribed by doctors. 1. Chemotherapy: commonly used chemotherapy drugs include etoposide, irinotecan, gemcitabine, paclitaxel and so on. Since the blood-brain barrier will prevent chemotherapeutic drugs from entering the brain, it is seldom used as the initial means to treat brain metastasis of small cell lung cancer. Temozolomide can cross the blood-brain barrier, so it can be used in the treatment of brain metastasis of small cell lung cancer. 3. Radiation therapy: it mainly includes prophylactic brain irradiation, whole brain radiation therapy, stereotactic radiation and so on. Usually, radiation therapy can kill cancer cells, so as to control the progression of disease and prolong the survival time. 4. Targeted therapy: commonly used targeted drugs in clinic include Anrotinib, Apatinib, etc. It is recommended that patients with small cell lung cancer brain metastasis should be treated with targeted therapy. It is recommended that people with brain metastasis of small cell lung cancer should choose appropriate treatment plan after evaluation by doctors, and they need to go to doctors for regular review during the treatment period in order to monitor the changes of their conditions.