Ultrasound ablation therapy depends on two basic conditions, one is the need for a suitable acoustic channel for ultrasound waves to penetrate and converge, so that an effective small focus of high-intensity ultrasound waves can be formed within the lesion in the body; the other is the tissue of the lesion to be prepared for treatment, which can produce a good acoustic effect on the high-intensity ultrasound waves, that is, the ultrasound waves can easily generate heat in such tissue. The diseases for which ultrasound ablation has been effectively applied in clinical practice and achieved certain efficacy are mainly some benign and malignant solid tissue lesions or tumors, as well as bone tumors. The main diseases include: 1, uterine fibroids; 2, uterine adenomyosis (also known as adenomyosis); 3, endometriosis of the abdominal wall (mostly seen around the surgical incision of cesarean section); 4, fibromatosis, also known as invasive fibroids; 5, primary liver cancer or metastatic liver cancer; 6, pancreatic cancer; 7, primary malignant bone tumors (osteosarcoma, Ewing’s sarcoma, chondrosarcoma, etc.); 8, soft tissue sarcoma; 9 Breast fibroids, breast cancer. Along with the development of ultrasound ablation technology, the scope of its clinical application will definitely be expanded, and the specific indications for each disease will need to be corroborated and precise through continuous clinical practice.