1.Acute and subacute adverse reactions Refers to allergy, malignant vomiting, diarrhea; hematology, liver and kidney function, finger numbness, rash, hand-foot syndrome and alopecia, etc. that occur within the then course of treatment after the drug is administered. 2, long-term adverse reactions Refers to the adverse reactions that occur after discontinuation of the drug or even years after discontinuation of the drug, including neurotoxicity, hematopoietic dysfunction, interstitial pneumonia, cardiotoxicity, endocrine disorders, malformations, etc. And according to the severity, it is divided into degree 1, 2, 3 and 4. degree 1 means mild reaction, degree 2 is moderate reaction, degree 3 is serious reaction, and degree 4 is serious adverse reaction that can be fatal. the WHO and the US NCI have clear regulations on the grading of adverse reactions in each system. It goes without saying that degree 1 and 2 are allowed in the process of treatment implementation, degree 3 should be avoided should adjust the dose, and degree 4 adverse reactions need to be discontinued immediately and treated, first aid.