The ketogenic diet is a formulated diet with a high proportion of fat, a low proportion of carbohydrates, and appropriate protein and other nutrients that does not interfere with normal growth and development, and at the same time has a therapeutic effect on epilepsy and tumors. It is now internationally accepted that the new anti-epileptic is only effective in 30-40% of children with refractory epilepsy (more than 50% reduction in seizures); while the ketogenic diet is effective in 50-80% of children with refractory epilepsy, and 30% of children can reduce seizures by 90%. The ketogenic diet can be used for the treatment of: 1) GLUT1 deficiency (Glucose transporter deficiency syndrome) 2) PDH deficiency (Pyruvate dehydrogenase deficiency) Severe infantile myoclonic epilepsy, myoclonic dystonic epilepsy, infantile spasms, and epilepsy caused by tuberous sclerosis have been reported to be more effective. Absolute contraindications to ketogenic diet Carnitine deficiency, Carnitine palmitoyltransferase I or II deficiency, Carnitine transferase II deficiency, β-oxidation deficiency, medium-chain acyl dehydrogenase deficiency, long-chain acyl dehydrogenase deficiency, short-chain acyl dehydrogenase deficiency, long-chain 3-hydroxy lipid acyl coenzyme deficiency, medium-chain 3-hydroxy lipid acyl coenzyme deficiency, pyruvate carboxylase deficiency, porphyria