Cirrhosis to hepatic ascites with tumor spreading to blood vessels is considered as cirrhosis causing hepatocellular carcinoma with hepatic ascites, which needs to be treated symptomatically and causally by general measures, medication, other treatments and surgical treatments. 1. Symptomatic treatment: for hepatic ascites, patients need to take bed rest, cooperate with doctors to adjust diet structure, protein control at 1~1.2g/kg, water intake limited at 800~1000ml/d, diet with high calorie, high protein, high vitamin, easy to digest, less salt or no salt. If the effect is not good, it is necessary to follow the medical advice to apply spironolactone, furosemide and other diuretics. 2. Causative treatment: patients need to apply hepatoprotective drugs such as diammonium glycyrrhizinate and glutathione, as well as targeted drugs such as sorafenib, lenvatinib and regorafenib as prescribed by the doctor. Secondly, patients also need to follow the doctor’s instructions to apply interferon α, thymosin α₁ and other immunomodulators. Chemotherapists need to cooperate with doctors to apply chemotherapeutic agents such as oxaliplatin and gemcitabine. Some patients also need to use drugs such as nabulirubicin monoclonal antibody and pabolizumab monoclonal antibody for immunotherapy, and patients can also take radiation therapy. In addition, surgical treatments such as hepatectomy and radiofrequency ablation can also be taken. In conclusion, when patients are found to have cirrhosis to liver ascites with tumor spreading to blood vessels, they need to go to the hospital in time.