In about one out of every hundred babies, one baby has congenital heart disease. This means that the population prevalence of congenital heart disease is 1% (0.6% – 1.2%), which is not a small number, and based on our population of 1.3 billion, there are about 13 million people suffering from congenital heart disease. Congenital heart disease is not a hereditary disease, but some families have more than one person suffering from congenital heart disease, or in the blood relations of people such as uncles, uncles, aunts, uncles, cousins with the disease. The chances of their children having the disease increase exponentially. Some chromosomal abnormalities are often associated with congenital heart disease, such as congenital stupidity (Down’s syndrome, i.e. trisomy 21) about 50% suffer from congenital heart disease, trisomy 18 about 90% suffer from congenital heart disease. Recently, due to the development of molecular biology, it has been found that more and more congenital heart diseases have common gene deletions, such as CATCH syndrome, which is a deletion of the short arm 11 locus of one of the 22nd chromosome pairs, and can be combined with tetralogy of Fallot, ventricular septal defect, permanent arterial trunk, and interrupted aortic arch. From the point of view of genetics, congenital heart disease is caused by heredity, and it is not the case that if the father or mother has heart disease, the child must have congenital heart disease, because the inheritance of congenital heart disease belongs to polygenic law, which is generally 3-5 times higher than the normal parents who do not have congenital heart disease, but it is important to note that if a family has both parents with congenital heart disease or other people also have congenital heart disease, the chance of the child being born with congenital heart disease will be greatly increased. However, it is important to note that if a family has both parents with congenital heart disease or others with congenital heart disease, the chance of the child being born with the disease will increase greatly. From the point of view of eugenics, it is better for a heart patient not to find a partner with a congenital heart disease, yo. Pregnant women with congenital heart disease should take care of their prenatal checkups.