Serum ferritin is one of the most iron-rich brown protein complexes in the body, with a molecular weight of about 450,000, which contains 17%-23% iron and is one of the main storage forms of iron. It is present in the reticuloendothelial system of the liver, spleen and bone marrow, supplying iron for the synthesis of hemoglobin by the bone marrow and releasing it into the serum according to the needs of the body. There are physiological reasons for the increase in synthesis, such as the high oxygen demand of some athletes and the corresponding increase in synthesized ferritin. Abnormal changes in serum serum ferritin can occur when there is a disease in one of the body systems. 1. The relationship with iron deficiency anemia Serum ferritin is measured is the best and most reliable diagnostic method for diagnosing occult iron deficiency anemia. Utilization disorders: there are problems with iron organism in the process of utilization, piling up, typically iron lytic anemia; more than 2/3 of uremic patients have elevated serum ferritin, mostly not due to iron deficiency, but greatly reduced erythropoietin when the kidney is damaged, thus affecting hematopoietic function as well as iron utilization disorders. 2.Relationship with tumor Synthesis increase: It is generally believed that serum ferritin in tumor patients is highest in hepatocellular carcinoma, followed by patients with lung cancer, leukemia and malignant lymphoma. 3.Relationship with liver Clearance disorders: liver ferritin contains about 1/3 of the stored iron in the body, and the ferritin in the blood circulation is removed by liver cells, so liver disease can cause an increase in serum ferritin General acute hepatitis acute stage, chronic hepatitis active stage, cirrhosis active stage, serum ferritin significantly increased, and the more serious liver cell damage, the higher the content. 4.Relationship with tuberculosis The measurement of serum ferritin in patients with tuberculosis can diagnose the severity of tuberculosis, guide the treatment and estimate the prognosis to assist in diagnosis. 5.Relationship with heart disease When the serum ferritin concentration in blood is overloaded, the incidence of heart disease will increase more than 3 times, mainly because the excess serum ferritin promotes the formation of free radicals, which can damage the arterial wall cells and thus damage the heart muscle. Therefore, adults should avoid blind iron supplementation.