Patients with stomach pain on an empty stomach that is relieved after a meal are most often seen with duodenal bulb ulcers. The main manifestation of duodenal bulb ulcer is chronic regular pain, often nocturnal pain and hunger pain, mainly due to hunger or increased gastric acid secretion at night, which causes irritating pain to the ulcer wall by large amount of gastric acid. The treatment of duodenal ulcer is mainly to remove the causative factors, control the symptoms, promote ulcer healing, prevent recurrence and avoid complications. For specific treatment, first, drugs that inhibit gastric acid secretion are given, choosing H2 receptor antagonists or proton pump inhibitors to promote ulcer surface repair by inhibiting gastric acid. Secondly, eradication of H. pylori is performed for peptic ulcers, whether active or not. Then, comprehensive treatment such as protection of gastric mucosa is given. Commonly used for protection of gastric mucosa are bismuth, weak alkaline antacids, etc. If the patient has poor results by medical treatment or there is a possibility of acute perforation, surgical treatment is performed. In conclusion, the healing rate of peptic ulcer is very high with effective treatment, but it is necessary to pay attention to the diet and work and rest routine and avoid the intake of spicy and irritating food.