[Abstract] Objective To summarize the care of nasopharyngeal ventilation tube retention after surgery for obstructive sleep apnea hypoventilation syndrome (OSAHS). Methods Eighty patients with OSAHS treated surgically from January 2008 to December 2012 in Coal General Hospital were selected, and the patients’ compliance with ventilator retention, changes in ventilator position and complications were analyzed; the key points of care were summarized. Results All patients received ventilation tract treatment and were withdrawn as scheduled. Nine of them had ventilation tract displacement within 24 h after surgery; two cases had complete obstruction of the ventilation tract within 24 h; five cases were found to have partial obstruction in the ventilation tract at 48 h extraction; three patients had dyspnea and six patients had pharyngeal tingling, and the examination revealed that the distal end of the ventilation tract was against the hypopharyngeal tissue and the airway position was too deep. Conclusion Standardized care is the key to ensure that OSAHS patients safely survive the perioperative risks, and is an important guarantee for the success of surgery in 0SAHS patients.