Contraindications to vaccination with the New Coronavirus vaccine are clearly defined in the “Technical Guidelines for Vaccination with the New Coronavirus (First Edition)” issued by the State Council, which states that vaccination with the New Coronavirus vaccine is not recommended for patients with uncontrolled epilepsy and the presence of other serious neurological diseases, such as Green-Barre syndrome, demyelinating disease and acute myelitis. However, for patients with stable epilepsy, vaccination can usually be administered after consultation with the vaccination site if the physical indications are normal and life is not affected. Because epilepsy is a chronic neurological disease, patients may experience uncontrolled convulsions, dizziness, convulsions, and fainting during the seizure phase of the disease. Vaccination not only makes vaccination more difficult, but also delays the treatment of epilepsy, and may induce adverse reactions such as fever and coma. And when epilepsy develops, it may directly trigger asphyxiation, which may pose a serious threat to the patient’s life. It is recommended that patients with epilepsy be treated for epilepsy first, and after the symptoms are stabilized and the disease is under control, they can bring their medical records and other materials to the hospital for examination, and then be vaccinated after permission is granted by a doctor or professional evaluation by the vaccination department. After vaccination, always pay attention to any abnormalities in yourself, and if you experience any uncomfortable symptoms, it is recommended to seek medical attention in a timely manner. In addition, with the gradual improvement of the research on the new crown vaccine, there may be some differences in the regulations of vaccination in each region, and patients are advised to consult their local vaccination department for detailed information.