Painful symptoms can occur in diabetes when peripheral neuropathy and diabetic foot occur. Diabetic peripheral neuropathy can occur when neuralgia, can also be accompanied by nociceptive allergy and other symptoms; diabetic foot can be lower extremity resting pain, tingling at the extremities and other symptoms. 1. Diabetic peripheral neuropathy: patients may experience neuralgia, which may be manifested as pins and needles, burning pain, gunshot pain, etc. It may also be accompanied by nociceptive allergy, and patients may feel severe pain when wearing shoes or socks. 2. Diabetic foot: patients may have tingling, burning pain and other pain sensations in the extremities, which may be accompanied by hypoesthesia or loss of sensation; there may also be lower limb ischemia manifestations, such as resting pain, arterial vascular pulsation weakened or disappeared. Patients with diabetes mellitus are advised to go to the hospital when pain symptoms occur.