Itchy testicular skin is not a precursor to AIDS. There are many possible causes for this condition, which need to be clarified by detailed examination. If itchy testicular skin is present, it is important to also look for skin breakdown, redness and swelling of the testicles, combined testicular and epididymal pain, and a history of diabetes. The common causes include scrotal skin eczema or fungal infection. In case of scrotal skin eczema, patients need to pay attention to personal hygiene, keep clean, avoid spicy and irritating diet, reduce skin irritation, and apply topical creams under the guidance of a doctor. If it is a fungal infection, patients can use antifungal ointment such as ketoconazole and pay attention to local cleanliness and dryness. The important manifestation of early AIDS is the appearance of elevated white hairy patches on the edge of the tongue, and the mere itchy skin on the exterior of the testicles cannot be taken as a characteristic manifestation of AIDS. Therefore, when itchy testicles appear, patients should not worry too much, but seek medical treatment as soon as possible, actively cooperate with the doctor in applying drugs, ensure hygiene and avoid scratching the affected area at will to get better treatment results.