Pulmonary hairy glass lesion is an imaging term for a small nodule in the lung that is not particularly homogeneous in density on CT presentation and is not a solid nodule, but rather a hairy glass-like nodule that has some probability of being malignant and requires some clinical or surgical intervention and management. If a patient has a hairy glass nodule in the lung, the possibility of inflammatory nodules, active tuberculosis, tumors, and other related diseases is not excluded. If the nodule is accompanied by irritating cough, metallic sound, weakness, wasting, chest pain, coughing up blood, dyspnea, etc., the possibility of malignant nodules is high and further biopsy or bronchoscopy of the nodule is needed. If the nodule is diagnosed as malignant, surgical evaluation is required, and surgical treatment is needed if there are indications for surgery, while radiotherapy, chemotherapy or targeted cell drug therapy can be considered if there are no indications for surgery. The presence of hairy glassy nodules is very important for further diagnosis and further therapeutic approaches based on the diagnosis. Inflammatory nodules are also very common and are reviewed after anti-infection and mostly return to full normal.