The order of metastasis in late stage of colon cancer is not absolute, but there are certain rules to follow. Generally speaking, there are two major metastatic pathways for colon cancer, namely bloodstream metastasis and lymphatic metastasis. In most cases, lymphatic metastasis appears first, starting with peri-intestinal lymph node metastasis, followed by mesenteric lymph node metastasis, and finally iliac lymph node metastasis and lymph node metastasis of distant organs in the body. The first site of hematogenous metastasis is the liver, then the lungs, and through the lungs to other parts of the body such as the bones and brain. Implantation metastasis can also occur in colon cancer patients, mainly when cancer cells are shed from the surface of the colon and implanted in the abdominal cavity to form metastatic lesions. Most of the time, implantation metastases appear after blood and lymphatic metastases, but some may appear first.