The common drugs used in chemotherapy for colon cancer are generally decided according to the patient’s condition, mainly the combination chemotherapy regimen consisting of fluorouracil and platinum chemotherapy drugs is more commonly used. Among the fluorouracil-based chemotherapy drugs, there is intravenous 5-fluorouracil, which should be combined with calcium folinic acid to enhance the efficacy and reduce the side effects. There are also 5-fluorouracil drugs that can be taken orally, such as Tegeo and Capecitabine. The exact use of intravenous or oral depends on the patient’s condition, but in general, oral fluorouracil analogs are more effective and have fewer side effects. Platinum agents such as oxaliplatin are most commonly used, and platinum agents such as cisplatin and carboplatin can also be used. For patients whose disease does not allow the use of platinum agents or who are resistant to platinum agents, they can also switch to irinotecan combined with fluorouracil. In addition, chemotherapy combined with anti-angiogenic agents, such as bevacizumab, may also increase the effect for the benefit of patients.