Impotence, also known as male erectile dysfunction, clinically includes a variety of general treatment, pharmacotherapy, psychotherapy, surgery and other treatment modalities, of which pharmacotherapy is the most commonly used and includes two more routes. First-line therapy: phosphodiesterase 5 inhibitors. Phosphodiesterase 5 is an enzyme widely distributed in penile cavernous tissue, referred to as PDE5. Inhibition of PDE5 activity can block cGMP hydrolysis and increase its concentration, inducing relaxation of penile blood vessels and cavernous sinus smooth muscle, which can induce penile erection by increasing blood flow in penile arteries. Highly selective PDE5 inhibitors, such as sildenafil, tadalafil and vardenafil. Penile cavernosal drug injection therapy: It is a second-line treatment by drug injection route. Vasodilator drugs such as prostaglandin E1, poppyrine, and phentolamine are injected into the penile corpus cavernosum, which can induce erection through local vasodilator effect. However, the dosage of drugs used and the method of drug injection must be determined under the guidance of a doctor to avoid serious complications. If the erection of the penis persists for more than 4h, it should be treated immediately by a doctor in an emergency. Therefore, medication is only one of the optional methods of impotence treatment, and the medication is also divided into two routes, oral and drug injection, each with different drugs, and patients can choose different options under the guidance of their doctors according to their conditions.