Tongue pain is a common disease of the oral mucosa. The pain is due to a variety of causes, the most common being mycotic papillitis and tongue pain. Mycotic papillitis is manifested as swollen and congested mycotic papillae, burning, swollen papillae with obvious protrusion, thin and deep red epithelium, strawberry-like changes, and obvious pain. treatment can be used to clear heat and detoxify Chinese medicine, such as stomatitis Qing granules, etc. 0.1% to 0.2% chlorhexidine gluconate solution, compound boric acid solution, 0.1% estradiene solution for gargling, and also lysozyme tablets, wazoo tablets, etc. containing. For specific medication, please refer to the clinical situation and follow the doctor’s instructions in face-to-face consultation. Tongue pain syndrome, also called burning mouth syndrome, is often seen clinically as “burning pain in the tongue”, but after clinical examination, the patient’s tongue and oral mucosa are normal. Burning mouth syndrome is a group of syndromes in which the tongue is the main site of onset and burning-like pain is the main manifestation, which usually occurs in menopausal women. Some patients have light sensory changes in the morning and heavy sensation in the evening, but there is no obvious damage by clinical examination. The burning pain mainly involves the tip of the tongue and the dorsum of the anterior two-thirds of the tongue. Most patients seen in the clinic are poor sleepers, suffer from anxiety or depression, and some are menopausal syndromes, which should be investigated in the relevant departments. It is possible that the oral condition is a somatic symptom of these diseases. In conclusion, the cause of pain in the tongue may be a disease of the tongue or it may be a reaction of a systemic disease in the oral cavity.