Genital herpes, also called recurrent herpes simplex, is one of the common STDs that is highly recurrent and has a major impact on the health, psychology and life of the patient. The disease is not only highly contagious, but can also lead to many complications if not treated promptly. The diagnosis of genital herpes requires antibody testing, cytology, serology, cell culture, and electron microscopy. Antibody testing is currently the most common test for genital herpes and involves taking a specimen from the affected area and testing for herpes simplex virus antigens. Cytological examination is performed by scraping a small amount of tissue from the base of the herpes or the ulcerated surface for smear, and microscopy can reveal characteristic multinucleated giant cells or intranuclear viral inclusion bodies. Serological tests are used to detect antibodies and to diagnose primary HSV infection. Cell culture is the most sensitive method for isolating the virus by taking material from the bottom of the blister and doing tissue culture, which usually takes 5-10 days. Electron microscopy mainly involves taking blister fluid or lesioned brain tissue filings and observing the virus particles under electron microscopy. Although genital herpes is prone to recurrence, patients do not have to be overly nervous and rush to the doctor, they should choose regular hospital treatment, use medication under the guidance of the doctor and reduce the recurrence rate by enhancing their own immunity.