1. Prescription Physiological saline 100ml + Omeprazole 40mg + Vitamin B6 0.3 Result: The infusion gradually turned yellow and finally black. Analysis: The combination of omeprazole and vitamin B6 has not been reported in the literature and is not described in the instructions. Omeprazole is an alkaline drug, can raise the PH value of saline, vitamin B6, also known as pyridoxine hydrochloride, containing phenolic hydroxyl, PH value of 3 ~ 4, the two effects of acid-base neutralization, discoloration may be the phenolic hydroxyl of vitamin B6 oxidation in alkaline conditions, so the two should not be dispensed in the same bottle of infusion. 2. Prescription: 25% glucose 40ml + 10% calcium gluconate + dexamethasone 5mg Result: Insoluble calcium salt precipitate was generated. Analysis: Calcium gluconate is forbidden to be combined with oxidizing agents, citrate, soluble carbonate, phosphate and sulfate, which will generate insoluble calcium salt precipitation (calcium gluconate drug instructions) and endanger life. So the two should be injected intravenously separately. 3, prescription: mannitol 250ml + dexamethasone 5mg. Results: Mannitol precipitation crystallization may occur. Analysis: mannitol is a tissue dehydration drug, dexamethasone has anti-inflammatory effect, the two together is conducive to the elimination of edema. Because 20% mannitol is a supersaturated solution, when combined with other drugs, the solubility of mannitol may be changed by the addition of new solutes and solvents and precipitation of mannitol crystals. Therefore, the two should be used separately, and should not be added to the same container for use. 4.Prescription: 25% glucose 40ml+Xidilan 0.4mg+Furosemide 20mg. intravenous injection Result: furanilic acid precipitate is generated Analysis: Furosemide is a weak acid and strong base salt, PH 8.5-10, forbidden to be used with acidic liquid, in acidic environment (25% glucose PH 3.5-5) furanilic acid precipitate is generated, which is life-threatening. It is possible to inject 25% dextrose + cidilan, NS + furosemide intravenously separately. Furosemide instructions state that furosemide should be diluted with saline rather than glucose. Allergy to sulfa drugs is prohibited. 5, prescription: glucose 250ml + vitamin K1 injection 40mg + vitamin C 3.0g Result: Redox reaction occurred between the two, making vitamin K1 less effective. Analysis: Vitamin C has strong reducing properties, and when mixed with the quinone drug vitamin K1, a redox reaction can occur, which reduces the efficacy of vitamin K1. Vitamin K1 injection and vitamin C injection were placed for a period of time, vitamin K1 was completely destroyed. 6, prescription: cimetidine injection combined with aminoglycoside antibiotics; cimetidine injection combined with clindamycin. Result: Respiratory depression. Analysis: Cimetidine, aminoglycoside antibiotics and clindamycin can bind to the calcium binding site on the presynaptic membrane at the neuromuscular junction and block the release of acetylcholine, producing a neuromuscular junction blocking effect. The combination of these antibiotics may cause respiratory depression, which may endanger life. Once respiratory depression occurs, calcium chloride should be injected immediately to counteract it. In addition, the combination of these drugs with anesthetics may cause respiratory muscle paralysis, so clinical application should also be noted. For more information about the adverse drug reactions and contraindications of cimetidine, please refer to the drug instruction manual. 7. Prescription: 3:2:1 injection 500ml + phenosulfacetamide injection 0.25 sig ivgtt Result: The color of the solution turned red after a few minutes. Analysis: Phenolsulfonamide can enhance platelet function and platelet adhesion, shorten clotting time, and reduce capillary permeability and prevent blood permeation. 3:2:1 solution contains 34ml of sodium bicarbonate, which is alkaline, and combined with phenolsulfonamide, because phenolsulfonamide contains phenolic hydroxyl group, it is easy to oxidize and discolor with alkaline drugs, the discoloration point PH is 6.7, so the two drugs together can easily discolor phenolsulfonamide. Reduced effectiveness. 8, prescription: 5% glucose injection + adenosine triphosphate 20mg + coenzyme A injection 100u + vitamin B6100mg Results: precipitation after mixing. Analysis: commonly used ATP-2Na, stable at PH 8-11, precipitation occurs when acidic, vitamin B6 is water-soluble pyridoxine hydrochloride, PH 3-4, which can cause ATP-2Na to precipitate. Therefore, avoid the same container in the static drop. 9.Prescription: 0.9% sodium chloride injection 100ml + flurofloxacin injection 0.2 sig ivgtt Result: After a few minutes, the solution formed a white mixed candle precipitate. Analysis: The [Precautions] in the instruction of fleroxacin injection clearly states: “Avoid combining with sodium chloride injection or sodium chloride glucose injection. Flurofloxacin injection and 0.9% sodium chloride injection can be combined to form a white precipitate, the precipitate Flurofloxacin. Flurofloxacin injection is made by using both acidic and basic groups in the structure of flurofloxacin, which can generate soluble salts with amino acids. The solubility of flurofloxacin is reduced in the electrolyte solution due to the homoion effect, resulting in the formation of particles that coalesce in a short time and generate precipitation. In addition, flurofloxacin is a fluoroquinolone, which contains the basic structure of quinoline ring skeleton and 3 fluorine atoms. The combination of this structure with chloride ions will lead to integration reaction, resulting in precipitation of macromolecular integrates, affecting the drug content and weakening the therapeutic effect. In clinical use, fleroxacin injection should never be combined with injections containing sodium chloride. That is, it should not be combined with sodium chloride injection or sodium chloride glucose injection. This product should not be mixed with other drugs. When preparing the infusion, it should be diluted in 5% glucose 250-500ml injection solution, and slowly infused intravenously with 0.2-0.4g once, once a day, away from light. The speed of intravenous drip should not be too fast, each 0.2g drip time is at least 45～60min Flurofloxacin is influenced by chloride ion, but the temperature and light also have some influence. When flurofloxacin is combined with 5% GS injection, the original colorless clarified liquid will turn into lavender after 20 minutes of sunlight exposure, so flurofloxacin injection should be stored away from light.