Patients with heartburn, shortness of breath and chest tightness first need to clarify the cause. If the symptoms are caused by physiological factors or environmental factors such as staying up late, emotional excitement, excessive stress, stuffy environment, etc., they generally only need to go through rest, open windows or go to places with air circulation, without necessarily taking drugs. However, long-term unrelieved, consider pathological factors, for the cause, there are generally the following drug treatment modalities: a. Cardiovascular disease: common coronary heart disease, myocardial infarction, heart failure, etc. 1. Anti-arrhythmic drugs: the main role is to terminate the arrhythmia attack, reduce the patient palpitations, angina, chest tightness, dizziness and other symptoms, improve the prognosis. Commonly used drugs include quinidine, phenytoin sodium, mexiletine, metoprolol, amiodarone, atropine, etc.; 2. Anti-myocardial ischemic drugs: the main purpose is to reduce myocardial oxygen consumption or dilate coronary arteries to relieve patients’ symptoms of chest tightness, panic or pain. Common isosorbide nitrate, esmolol, calcium channel blockers, etc. Second, respiratory system diseases: common asthma, chronic obstructive pulmonary disease, chronic bronchitis, etc. 1, diastolic bronchial drugs: commonly used salbutamol, salmeterol, ipratropium bromide, theophylline extended-release tablets and other drugs act on the bronchial tubes to relieve bronchospasm and improve symptoms; 2, expectorant drugs: commonly used aminoglutethimide hydrochloride, acetylcysteine, hydroxymethystane, etc., help cough up sputum and relieve the symptoms of dyspnea 3, hormonal drugs: including drugs that help inhibit airway inflammation, commonly used beclomethasone, budesonide, mometasone, ciclesonide and other inhalation therapy, or prednisone, prednisolone and other oral. For patients with panic attacks, shortness of breath and chest tightness, if the influence of physiological factors is ruled out, they should promptly visit a hospital to clarify the cause and then undergo treatment. Some patients may also need antithrombotic therapy, antiplatelet therapy, and surgical treatment to relieve symptoms.