There is no standard absolute answer for how long a patient can live with advanced thyroid cancer, and the survival rate varies depending on the type of pathology, stage and patient condition. After ensuring proper treatment, patients should usually pay attention to spiritual adjustment, eliminate the worries about how long they can live with advanced thyroid cancer, lift the mental burden and maintain a happy mood for a long time, the survival period may be extended. Even if a large amount of data is given clinically, it is not possible to make a generalization. Patients with advanced thyroid cancer will have a variety of clinical symptoms in the weeks or months before death, the common ones include pain, weakness, fatigue, nausea, vomiting, shortness of breath, anorexia, and mental symptoms such as depression, anxiety, insomnia, extreme excitement, etc. Once thyroid cancer reaches an advanced stage with the above symptoms, how long can patients live with advanced thyroid cancer is a question that patients and their family members are eager to seek proof. The treatment of advanced thyroid cancer is a systematic process, and how long the patient can live depends not only on the patient’s strong will and strong desire to live, but also on the appropriateness of the treatment method and the differentiation of the disease. Generally, for well-differentiated thyroid cancer such as papillary and follicular carcinoma, the long-term survival rate is high through surgery and radioiodine treatment; while for some patients with advanced thyroid cancer showing extensive infiltration or distant metastasis, the aim of treatment is to reduce symptoms and prolong life. In the course of advanced treatment, patients and their family members should promptly observe the improvement of patients’ lesions and communicate more with the treating physicians to evaluate the treatment effect in order to improve the treatment methods.