SLE primarily affects women of childbearing age with an increased risk of multiple adverse pregnancy outcomes, including miscarriage, stillbirth, and preterm delivery.SLE can affect pregnancy outcomes for which the risk factors are: lupus nephritis and antiphospholipid antibody positivity. Lupus nephritis has been identified as a risk factor for hypertension and pre-eclampsia. Women with SLE with underlying nephropathy may have increased proteinuria during pregnancy, and in most cases it is not difficult to identify pre-eclampsia from active lupus nephritis. Active lupus nephritis is supported when serum complement levels are reduced and there is evidence of active urinary sedimentation and systemic lupus activity. Other manifestations such as hypertension, thrombocytopenia, increased serum uric acid levels and proteinuria are present in both active lupus nephritis and pre-eclampsia. Pregnancy itself can cause hypoactivation of the classical pathway of complement. Patients with SLE have a higher incidence of spontaneous abortion, intrauterine fetal death and preterm delivery than normal women. The timing of pregnancy is best when the disease has been in clinical remission for 6-12 months and renal function is stable and at or near normal. That is why contraception and family planning are more important. Management of pregnancy in SLE: 1. Planning pregnancy: determine that lupus is in inactive phase for at least 6 months, and discourage pregnancy if creatinine is greater than 167umol/L; 2. Testing for antiphospholipid antibodies and other antibodies that may be associated with pregnancy events (e.g. anti-SSA, anti-SSB antibodies); 3. Baseline testing for laboratory indicators (serology, blood biochemical indicators including creatinine, albumin, uric acid, anti-ds DNA, C3, C4); 4. Pay attention to the risk of congenital heart block (CHB), especially in women with anti-SSA and anti-SSB antibodies or who have previously given birth to a baby with CHB; such female patients should be tested for CHB between 16-24 weeks of gestation; 5. Closely test blood pressure and proteinuria. If present, identify active nephritis or preeclampsia; 6. For patients with antiphospholipid syndrome, consider a combination of heparin and aspirin to reduce the risk of pregnancy failure and thrombosis.