Bitter mouth accompanied by dry mouth is most closely related to the gastrointestinal tract and the function of the gallbladder. When there are gallbladder diseases such as cholecystitis, gallstones, abnormal biliary tract function and a series of other diseases, the gallbladder bile will be abnormally secreted into the gastrointestinal tract. When the digestive function of the gastrointestinal tract is poor, it is also likely to affect the bile excretion in the bile duct. This results in the symptoms of bitter and dry mouth. If the bitter mouth is accompanied by a series of symptoms such as loose stools and abdominal pain, it is often related to the inflammation of the gastrointestinal tract and the gallbladder, and can be treated with some anti-inflammatory drugs, such as quinolones or aminoglycosides, which can effectively relieve the symptoms of inflammation of the gallbladder and the gastrointestinal tract. Abnormalities in the gallbladder may also lead to vague pain in the right abdomen under the rib cage. This can be observed. In case of dry mouth, it is also important to differentiate the diagnosis from fluid deficiency and endocrine disorders, such as diabetes mellitus. In addition, when the body has symptoms of fire, such as often eat spicy food or particularly stimulating food, it is also likely to produce symptoms of dry mouth and bitterness. In short, the causes of dry mouth are related to gallbladder, stomach and metabolic diseases, and a systematic diagnosis is necessary to determine the cause.