The most common problem of knee pain in middle-aged and elderly people is osteoarthritis of the knee, which is a manifestation of age-related degeneration. The disease is categorized into early, middle, and late stages, with different treatments for each stage. Early common patellofemoral arthritis, manifested as pain in the anterior part of the knee when going up and down the stairs, walking on the level road is no obvious symptoms; mid-range knee pain will be aggravated, the joint space becomes narrow; late knee deformation, inward or outward deformity, resting pain, etc., which seriously affects the quality of life of middle-aged and elderly patients. Early treatment suggestions are as follows: 1, first of all, according to the characteristics of the pain to change the habits of life, try to avoid going up and down the stairs or squatting and other sports; 2, oral tonifying the kidney and blood traditional Chinese medicine; 3, oral bisacodyl or glucosamine sulfate capsules and so on; 4, external medication fumigation and other treatments. Medication and precautions are the same as those in the early stage, if necessary, it can be combined with knee arthroscopy, and recently there is a surgical method called propped tibial osteotomy, which has a better surgical effect. Late treatment: If the knee pain worsens and seriously affects the patient’s quality of life, artificial joint replacement surgery can be used.