The platelet ratio is the proportion of large platelets to the total platelets in the blood, and the normal range is usually 17.5 to 42.3%. It is one of the routine blood tests in clinical medicine, but the value may vary due to differences in testing methods and instruments in different laboratories. The platelet ratio is not sensitive to the diagnosis of disease, and only when the value is higher than 10% does it have some diagnostic significance for the human body. The causes of high platelet ratio are divided into physiological and pathological causes. I. Physiological causes: Commonly, such as eating, insufficient body water, strenuous exercise and other causes of the body’s blood viscosity increased, may also lead to high platelet ratio, this situation does not require special treatment, most cases can be adjusted by increasing water consumption, rest, etc., a few days later re-examination, the index returned to normal. The main reason is that the body will make up for the high platelet ratio by releasing a large number of large platelets (i.e. immature platelets) in order to maintain the normal coagulation function, which should be treated systematically by the doctor in time. Preferred glucocorticoid therapy, or you can use immunosuppressants, gammaglobulin, etc. to enhance platelets, when the treatment is not effective, you can also choose cyclosporine, etc.; 2, primary thrombocytosis: mainly because of the active proliferation of bone marrow megakaryocytes resulting in an increase in the number of large platelets, at this time, you should promptly seek medical advice, understand the risk stratification of the disease, take the appropriate treatment, the main purpose of treatment is to prevent thrombosis and bleeding, such as Bone marrow inhibitors can be applied to gradually restore or approach normal platelet count in the blood, common drugs include hydroxyurea, interferon, aspirin, etc. At the same time in daily life should quit smoking and alcohol, control blood pressure, blood sugar, etc.; 3, acute granulocytic leukemia: some patients may also have high large platelet ratio, this type of patients should pay special attention to try to avoid the occurrence of infection and bleeding, need to take comprehensive treatment means, such as chemotherapy, radiotherapy and other ways, in life should pay attention to ensure enough rest, drink more water, avoid strain, bump, use flossing, wearing tight clothes, etc. In addition, there are acute septic infection, acute blood loss, hemolytic anemia, post-splenectomy true erythrocytosis and other diseases may lead to high platelet ratio, at this time, we should promptly seek medical attention, with other auxiliary examinations, such as bone marrow aspiration, blood routine results, etc., and then combined with the patient’s medical history, clinical manifestations and other comprehensive judgment, after a clear diagnosis according to the corresponding etiology or symptoms of comprehensive treatment.